AICAR 50mg (Research Grade)

Product Specifications:
• Chemical Name: 5-Aminoimidazole-4-carboxamide ribonucleotide (Acadesine)
• Molecular Formula: C9H15N4O8P
• Molecular Weight: 338.21 g/mol
• CAS Number: 2627-69-2
• Total Active Mass: 50mg per vial
• Physical Profile: Lyophilized white powder / crystalline solid

Product Overview:
AICAR is a cell-permeable, synthetic purine nucleoside analogue that acts as a direct metabolic regulator. Upon cellular uptake, it undergoes phosphorylation by adenosine kinase to form AICAR monophosphate (ZMP). ZMP structurally mimics adenosine monophosphate (AMP) closely enough to bind to the AMP-activated protein kinase (AMPK) complex, activating it without altering intracellular ATP, ADP, or AMP ratios.

Investigational Vectors:
1. AMPK Pathway Activation: Researchers study the compound’s capability to stimulate glucose uptake, fatty acid oxidation, and mitochondrial biogenesis across cell cultures.
2. Ischemic Preconditioning: In vitro and animal models evaluate the compound’s regulatory impact on adenosine transport and cardioprotective pathways during hypoxic or ischemic cellular stress mapping.
3. Cellular Autophagy & Transcription: Investigated for its down-stream signaling effects on the mTOR pathway, glucose transporter 4 (GLUT4) translocation, and skeletal muscle gene expression cascades.

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