FOXO4-DRI 10mg (Research Grade)

Product Specifications:
• Sequence: H-L-L-K-E-A-L-L-K-E-L-L-K-E-A-L-L-K-E-L-L-K-E-A-L-L-K-E-L-L-K-E-A-L-L-K-E-L-L-K-E-L-L-K-OH (All D-Form Amino Acids)
• Molecular Formula: C228H423N57O64
• Molecular Weight: 4975.25 g/mol
• Total Active Mass: 10mg per vial
• Structural Feature: Retro-Inverso peptide synthesized completely with D-amino acids for optimized proteolytic resistance
• Physical Profile: Homogeneous, white lyophilized cake

Product Overview:
FOXO4-DRI (Forkhead Box O4 D-Retro-Inverso) is a specialized 44-amino acid peptide synthesized entirely with D-amino acids in a reversed sequence configuration. This structural design isolates the peptide from typical enzymatic degradation by endopeptidases in vitro. In cellular senescence and longevity research models, FOXO4-DRI functions as a targeted antagonist that competitively disrupts the critical intracellular binding interface between the FOXO4 transcription factor and the p53 tumor suppressor protein.

Investigational Vectors:
1. Senolytic Apoptosis Induction: Researchers study the peptide’s mechanism for breaking the p53-FOXO4 complex, allowing p53 to translocate out of the nucleus to target mitochondria and trigger selective apoptosis in senescent cells.
2. Cellular Ageing Biomarkers: In vitro and animal models evaluate the compound’s impact on reducing the expression of the Senescence-Associated Secretory Phenotype (SASP), including pro-inflammatory cytokines like IL-6.
3. Tissue Regeneration Dynamics: Investigated for its regulatory role in cellular niche environments, specifically examining its impact on restoring tissue homeostasis, muscle fiber density, and fur density patterns in accelerated-ageing mouse models.

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