Product Specifications:
• Sequence: Aib-His-D-2-Nal-D-Phe-Lys-NH2
• Molecular Formula: C38H49N9O5
• Molecular Weight: 711.86 g/mol
• CAS Number: 170851-70-4
• Total Active Mass: 5mg per vial
• Physical Profile: Homogeneous, white lyophilized cake
Product Overview:
Ipamorelin is a synthetic pentapeptide that functions as a highly selective agonist of the growth hormone secretagogue receptor (GHS-R). While it mimics the binding mechanism of endogenous ghrelin similar to older generation secretagogues, Ipamorelin is unique due to its structural selectivity. In endocrine and metabolic research models, it is utilized to study somatotroph-specific growth hormone amplification without cross-activating secondary neuroendocrine pathways.
Investigational Vectors:
1. Selective Somatotroph Transcription: Researchers evaluate the compound’s binding kinetics at the GHS-R locus to map growth hormone release signaling while strictly tracking the absence of baseline fluctuations in cortisol, prolactin, or ACTH serum levels.
2. Dual Secretagogue Synergy: In vitro and animal models evaluate how Ipamorelin co-administration alongside Growth Hormone-Releasing Hormone (GHRH) or its analogues (such as CJC-1295) alters the cumulative volume of the pulsatile release envelope.
3. Gastric Homeostasis Modeling: Investigated for its peripheral regulatory role, specifically examining how its ghrelin-mimetic profile impacts gastric emptying rates and gastrointestinal kinetic pathways during metabolic mapping.
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