Product Specifications:
• Sequence: His-D-2-Nal-Ala-Trp-D-Phe-Lys-NH2
• Molecular Formula: C47H58N12O6
• Molecular Weight: 887.04 g/mol
• CAS Number: 140703-51-1
• Total Active Mass: 5mg per vial
• Physical Profile: Homogeneous, white lyophilized cake
Product Overview:
Hexarelin Acetate (also known as Examorelin) is a highly potent, structurally stable synthetic hexapeptide that functions as a selective agonist of the growth hormone secretagogue receptor (GHS-R). Chemically related to GHRP-6 but displaying enhanced structural modifications, Hexarelin is utilized in endocrine and cardiovascular research settings to analyze downstream cellular cascades, somatotroph signaling kinetics, and direct receptor-mediated cellular preservation mechanisms.
Investigational Vectors:
1. High-Affinity GHS-R Amplification: Researchers evaluate the compound’s capability to induce intracellular calcium mobilization and stimulate growth hormone release signaling independent of native GHRH pathways.
2. Myocardial Protective Pathways: Hexarelin is uniquely studied for its binding affinity to the CD36 scavenger receptor. Cell culture and animal models evaluate its impact on protecting cardiac tissue against induced ischemia-reperfusion injury, apoptosis, and oxidative cellular stress.
3. Desensitization Kinetics: Investigated to map pituitary receptor downregulation thresholds, observing how continuous baseline exposure alters secondary secretagogue responsiveness.
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