CJC-1295 (No DAC) 5mg (Research Grade)

Product Specifications:
• Chemical Name: Modified Growth Hormone-Releasing Factor (1-29)
• Molecular Formula: C152H252N44O42
• Molecular Weight: 3367.97 g/mol
• CAS Number: 863288-34-0
• Total Active Mass: 5mg per vial
• Physical Profile: Homogeneous, white lyophilized cake

Product Overview:
CJC-1295 without DAC (also known as Modified GRF 1-29) is a synthetic analog of endogenous Growth Hormone-Releasing Hormone (GHRH). By substituting four specific amino acids in the sequence (at positions 2, 8, 15, and 27), this compound is structurally modified to offer greater metabolic stability and resistance to dipeptidyl peptidase-4 (DPP-4) enzymatic cleavage in vitro compared to native GHRH (1-29).

Investigational Vectors:
1. Pituitary Somatotroph Binding: Researchers evaluate the compound’s binding affinity to growth hormone-releasing hormone receptors (GHRHR) to map cellular signal transduction cascades.
2. Pulsatile Secretory Dynamics: In vitro and animal models study how the absence of a Drug Affinity Complex (DAC) allows for natural, pulsatile growth hormone release modeling rather than continuous, baseline elevation.
3. Intracellular cAMP Signaling: Investigated for its regulatory impact on adenylyl cyclase activation and downstream cyclic adenosine monophosphate (cAMP) accumulation patterns.

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